Selected Publications


(See the full list at Google Scholar)

(2026). Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts. Epilepsia.

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(2026). Genetic regulation of methylation across East Asian and European populations. Nature Communications, 17(1), 2616.

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(2025). Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank. Journal of Affective Disorders, 381, 350-359.

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(2025). Paternal age, de novo mutation, and age at onset among co-affected schizophrenia sib-pairs: whole-genome sequencing in multiplex families. Molecular Psychiatry, 30(8), 3560-3567.

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(2023). Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits. Cell Genomics, 3(12):100436.

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(2023). Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores. Nature Genetics, 55, 1769–1776.

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(2022). Taiwan Biobank: a rich biomedical research database of the Taiwanese population. Cell Genomics, 2(11): 100197.

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(2022). Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach. BMC Genomics, 23(1), 385.

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(2022). Improving polygenic prediction in ancestrally diverse populations. Nature Genetics, 54(5), 573–580.

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(2021). Estimating cell-type-specific DNA methylation effects in heterogeneous cellular populations. Epigenomics, 13(2), 87–97.

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(2021). Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders. Biological Psychiatry, 89(1), 20-31.

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(2019). Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals. The American Journal of Human Genetics, 105(2), 267-282.

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(2019). Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nature Communications, 10(1), 1776.

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