Article-Journal

Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts

This study was undertaken to evaluate the predictive, stratification, and prognostic utility of polygenic risk scores (PRSs) for …

Ke, Y.-S., Tsai, M.-H., Ho, C.-R., Chou, C.-Y., Chen, H.-H., Stevelink, R., ..., Sung, S.-F., Lee, M.-C., Chen, J.-T., & Feng, Y. A.*

Genetic regulation of methylation across East Asian and European populations

Methylation quantitative trait loci (mQTL) studies have predominantly focused on European populations (EUR), limiting understanding of …

Liu, R., Chen, T.-T., Xia, Y., Lin, S.-C., Ge, T., Chen, C.-Y.*, Feng, Y. A.*, Huang, H.*, & Lin, Y.-F.*

Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank

Treatment-resistant depression (TRD) affects one-third of major depressive disorder (MDD) patients. Previous pharmacogenetic studies …

Wang, L.-H., Shih, M.-Y., Lin, Y.-F., Kuo, P.-H., & Feng, Y. A.*

Paternal age, de novo mutation, and age at onset among co-affected schizophrenia sib-pairs: whole-genome sequencing in multiplex families

Whether delaying fatherhood leads to more mutations, thereby resulting in adverse psychiatric outcomes in offspring, remains under …

Feng, Y. A., Chen, W. J., Lin, M. C., Hsu, J. S., Cheng, C. F., Liu, C. H., Hwu, H. G., Huang, Y. T., Lu, T. P., & Wang, S. H.

Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits

Genome-wide association studies (GWASs) have identified tens of thousands of genetic loci associated with human complex traits. …

Chen, C. Y.*, Chen, T. T., Feng, Y. A.*, Yu, M., Lin, S. C., Longchamps, R., Wang, S. H., Hsu, Y. H., Yang, H. I., Kuo, P. H., Daly, M. J., Chen, W. J., Huang, H.*, Ge, T.*, & Lin, Y. F.*

Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

Genome-wide association studies (GWASs) have been mostly conducted in populations of European ancestry, which currently limits the …

Campos, A. I., Namba, S., Lin, S. C., Nam, K., Sidorenko, J., Wang, H., Kamatani, Y., Biobank Japan Project, Wang, L. H., Lee, S., Lin, Y. F., Feng, Y. A., Okada, Y., Visscher, P., & Yengo, L.

Taiwan Biobank: a rich biomedical research database of the Taiwanese population

The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20-70 in Taiwan. A comprehensive list of …

Feng, Y. A.*, Chen, C. Y., Chen, T. T., Kuo, P. H., Hsu, Y. H., Yang, H. I., Chen, W. J., Shen, C. Y., Ge, T., Huang, H., Lin, Y. F.*

Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach

Background: As genomic sequencing moves closer to clinical implementation, there has been an increasing accept‐ ance of returning …

Feng, Y. A.*, Stanaway, I. B., Connolly, J. J., Denny, J. C., Luo, Y., Weng, C., Wei, W.-Q., Weiss, S. T., Karlson, E. W., & Smoller, J. W.*

Improving polygenic prediction in ancestrally diverse populations

Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) …

Ruan, Y., Lin, Y.-F., Feng, Y. A., Chen, C.-Y., Lam, M., Guo, Z., Stanley Global Asia Initiatives, He, L., Sawa, A., Martin, A. R., Qin, S., Huang, H., & Ge, T.

Estimating cell-type-specific DNA methylation effects in heterogeneous cellular populations

Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type …

Feng, Y. A.*, Guo, Y., Pain, L., Lathrop, G. M., Laprise, C., Moffatt, M. F., Cookson, W. O., & Liang, L.*

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

Genome-wide analyses of common and rare genetic variations have documented the heritability of major psychiatric disorders, established …

Lee, P. H., Feng, Y. A., & Smoller, J. W.

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious …

Feng, Y. A., Howrigan, D. P., Abbott, L. E., Tashman, K., Cerrato, F., Singh, T., ..., Daly, M. J., Lander, E. S., Lowenstein, D. H., Goldstein, D., Lerche, H., Berkovic, S. F., & Neale, B. M. (Epi25 Collaborative)

Polygenic prediction via Bayesian regression and continuous shrinkage priors

Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic …

Ge, T., Chen, C.-Y., Ni, Y., Feng, Y. A., & Smoller, J. W.