Article-Journal

Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank

Wang, L.-H., Shih, M.-Y., Lin, Y.-F., Kuo, P.-H., & Feng, Y. A.*

Paternal age, de novo mutation, and age at onset among co-affected schizophrenia sib-pairs: whole-genome sequencing in multiplex families

Feng, Y. A., Chen, W. J., Lin, M. C., Hsu, J. S., Cheng, C. F., Liu, C. H., Hwu, H. G., Huang, Y. T., Lu, T. P., & Wang, S. H.

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

Identifying genetic risk factors for highly heterogeneous disorders such as epilepsy remains challenging. Here we present, to our …

Epi25 Collaborative

Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits

Genome-wide association studies (GWASs) have identified tens of thousands of genetic loci associated with human complex traits. …

Chen, C. Y.*, Chen, T. T., Feng, Y. A.*, Yu, M., Lin, S. C., Longchamps, R., Wang, S. H., Hsu, Y. H., Yang, H. I., Kuo, P. H., Daly, M. J., Chen, W. J., Huang, H.*, Ge, T.*, & Lin, Y. F.*

Taiwan Biobank: a rich biomedical research database of the Taiwanese population

The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20-70 in Taiwan. A comprehensive list of …

Feng, Y. A.*, Chen, C. Y., Chen, T. T., Kuo, P. H., Hsu, Y. H., Yang, H. I., Chen, W. J., Shen, C. Y., Ge, T., Huang, H., Lin, Y. F.*

Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach

Background: As genomic sequencing moves closer to clinical implementation, there has been an increasing accept‐ ance of returning …

Feng, Y. A.*, Stanaway, I. B., Connolly, J. J., Denny, J. C., Luo, Y., Weng, C., Wei, W.-Q., Weiss, S. T., Karlson, E. W., & Smoller, J. W.*

Improving polygenic prediction in ancestrally diverse populations

Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) …

Ruan, Y., Lin, Y.-F., Feng, Y. A., Chen, C.-Y., Lam, M., Guo, Z., Stanley Global Asia Initiatives, He, L., Sawa, A., Martin, A. R., Qin, S., Huang, H., & Ge, T.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. …

Lee, P. H., Anttila, V., Won, H., Feng, Y. A., Rosenthal, J., Zhu, Z., ..., Smoller, J. W. (Cross-Disorder Group of the Psychiatric Genomics Consortium)

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious …

Feng, Y. A., Howrigan, D. P., Abbott, L. E., Tashman, K., Cerrato, F., Singh, T., ..., Daly, M. J., Lander, E. S., Lowenstein, D. H., Goldstein, D., Lerche, H., Berkovic, S. F., & Neale, B. M. (Epi25 Collaborative)

Polygenic prediction via Bayesian regression and continuous shrinkage priors

Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic …

Ge, T., Chen, C.-Y., Ni, Y., Feng, Y. A., & Smoller, J. W.