Taiwan Biobank Cohort Paper

“Taiwan Biobank: A rich biomedical research database of the Taiwanese population” published in Cell Genomics

Delayed fatherhood has long been linked to an increased risk of schizophrenia in offspring, but the underlying mechanism remains unclear. In collaboration with Dr. Shi-Heng Wang from the NHRI, we performed trio analysis on schizophrenia sib-pairs to identify de novo mutations (DNMs). We discovered that DNMs were associated with both advanced paternal age and an earlier schizophrenia onset in probands. Further, causal mediation analysis showed that DNMs significantly mediated the effect of paternal age on the age of schizophrenia onset. Our study offers a potential causal explanation linking paternal age-related mutations to increased psychiatric risk in offspring.

Reference:
Feng, Y. A.*, Chen, C. Y., Chen, T. T., Kuo, P. H., Hsu, Y. H., Yang, H. I., Chen, W. J., Shen, C. Y., Ge, T., Huang, H., Lin, Y. F.* (2022). Taiwan Biobank: a rich biomedical research database of the Taiwanese population. Cell Genomics, 2(11): 100197.